40 Demyelinating Diseases
MS
- weakness of arm, tingling of face, then go away; then second symptoms
- very very tired after hot shower: less nerve transmission
- Myelin basic protein one of the antigens
- type 4 but has antibodies
Symptoms
- pain/loss of vision in one eye
- Internuclear ophthalmoplegia: double vision/diplopia
- bladder: spasm or fail to sense
- oligoclonal bands: protein of certain size
- newer agents: don't know how they work
Guillain Barre
- endoneurium classically affected
- SCD: sudden cardiac death
- weak respiratory muscles: support breathing
PML
Posteinfectious encephalomyelitis
Charcot - Marie - Tooth
- weakness and severe deformities in lower extremities and feet
Krabbe
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